Publications

Research Highlights

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
JACC Cardiovascular Imaging
January 13, 2021
Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure
A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.
BMC Health Economics Review
May 23, 2019
Strain‐encoded magnetic resonance: a method for the assessment of myocardial deformation
This clinical review article describes the history and evolution of the MyoStrain technology. The manuscript itself provides a detailed summary of existing literature about MyoStrain and its predecessor technologies HARP and SENC, totaling 400+ publications representing 70,000+ patient data points to date.
ESC Heart Failure Journal
April 25, 2019
Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021

Select MyoStrain® Publications

The MyoStrain technology is rigorously validated across 500+ peer-reviewed publications (including 50+ in JACC and Circulation) representing more than 80,000 patient data points. The following selection contains the most recent and pivotal articles not highlighted above.

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Effect of comprehensive initial training on the variability of left ventricular measures using fast-SENC cardiac magnetic resonance imaging
An article discussing the effects of experience using MyoStrain on accuracy of test results, this article demonstrates consistency and reproducibility of MyoStrain results independent of operator expertise.
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Technical Comparison
August 21, 2019
Scientific Reports
Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement
This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.
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Chronic Diseases
August 8, 2019
Journal of Cardiovascular Magnetic Resonance
Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function
As a new approach for the rapid assessment of intra-myocardial dysfunction, this paper looks at the speed and clinical efficiency of MyoStrain. Through this method, Myostrain demonstrates rapid quantification of myocardial strain, helping to overcome lengthy CMR scan times and capacity issues.
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Technical Comparison
March 5, 2019
BMC Cardiovascular Disorders
The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension
This publication examines the use of MyoStrain myocardial strain assessment to detect right ventricular dysfunction in patients with pulmonary hypertension.
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Chronic Diseases
February 1, 2019
International Journal of Cardiovascular Imaging
Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging
In this paper, the authors demonstrate the reproducibility of myocardial strain derived from MyoStrain (fast-SENC) in the quantification and assessment left ventricular heart function.
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Technical Comparison
September 20, 2018
Scientific Reports
Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines
This paper demonstrates the clinical application of MyoStrain in the detection of subclinical dysfunction for asymptomatic pediatric cancer patients exposed to anthracycline chemotherapy. Authors used MyoStrain to identify abnormalities using tagging-based segmental myocardial strain.
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Cardio-oncology
May 1, 2018
Cardio-Oncology
Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method
Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.
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Cardio-oncology
May 13, 2016
Cardiology Journal
The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR
To demonstrate the prognostic value of strain, this study compares the sensitivity of MyoStrain global circumferential strain (GCS) in measuring contractile dysfunction against left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE).
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Technical Comparison
April 15, 2015
JACC Cardiovascular Imaging
Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA)
As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.
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Chronic Diseases
September 15, 2014
Journal of Magnetic Resonance Imaging