COVID-19

The Cardiovascular Impact of COVID-19

Physicians are just beginning to understand the effects of COVID-19 on the heart. In fact, a study published in 2020 shows 78% of COVID patients had some form of cardiac involvement following recovery,[1] and 60% had ongoing myocardial inflammation.[2] The majority of patients had recovered at home, and none had prior known cardiovascular issues.[1] Moreover, 25% of recovered COVID patients experience long-lasting symptoms including chest pain, high cholesterol and high blood pressure, all of which may be symptoms of heart disease.[3] As a result, patients with past COVID diagnoses–especially those with preexisting heart conditions–may be at a higher risk of developing worsening cardiovascular complications, such as myocarditis and pericarditis.[2] This highlights the need for highly sensitive, rapid and safe diagnostics to monitor and manage the potential long-term effects of COVID-19 on the heart.

MyoStrain provides a sensitive and accurate heart health assessment for recovered COVID-19 patients.[4] Complete in under 10 minutes, MyoStrain gives clinicians novel cardiac insights to detect the early cardiac effects of COVID-19, enabling opportunities to monitor changes in heart health over time and optimize treatment for improved outcomes and quality of life.

Cardio-oncology Publications

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
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Cardio-oncology
June 15, 2021
Circulation: Cardiovascular Imaging
CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography
This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019
CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment
This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019

Chronic Disease Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement
This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.
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Chronic Diseases
August 8, 2019
Journal of Cardiovascular Magnetic Resonance

Stress Testing Publications

Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain
This study indicates that in patients presenting with acute chest pain and inconclusive initial clinical screening, MyoStrain can be used to rule out obstructive coronary artery disease. These results show that MyoStrain may serve as a fast and accurate diagnostic tool that could be integrated into clinical workflows.
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Stress Testing
May 3, 2021
PLoS ONE
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
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Stress Testing
April 15, 2021
JACC: Cardiovascular Imaging
Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance
In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.
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Stress Testing
September 1, 2019
Journal of Magnetic Resonance Imaging

Heart Failure Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging
MyoStrain revealed that the LV septum is the location affected most, with reduced values visible in HFpEF and further reductions in HFmrEF and HFrEF where traditional CMR did not detect. This may hold significant socioeconomic implications, possibly aiding the identification of millions of presumable healthy individuals at risk for heart failure, who could benefit from early risk control and treatment.
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Heart Failure
April 1, 2021
ESC Heart Failure
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
References

[1] Walter, M. (2020). 78% of COVID-19 patients show signs of heart damage after recovery. Cardiovascular Business. https://www.cardiovascularbusiness.com/topics/covid-19/78-covid-19-patients-heart-damage-recovery. [2] Puntmann, V. O., Carerj, M. L., Wieters, I., Fahim, M., Arendt, C., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa-Nicotera, M., Zeiher, A. M., Vehreschild, M., & Nagel, E. (2020). Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA cardiology, 5(11), 1265–1273. https://doi.org/10.1001/jamacardio.2020.3557. [3] Ducharme, J (2021). Almost 25% of COVID-19 Patients Develop Long-Lasting Symptoms, According to a New Report. Time. https://time.com/6073522/long-covid-prevalence/. [4] Kelle, S.,  Society for Cardiovascular Magnetic Resonance (SCMR) recommended CMR protocols for scanning patients with active or convalescent phase COVID-19 infection. 22, 61 (2020). https://doi.org/10.1186/s12968-020-00656-6.et al. J Cardiovasc Magn Reson