Chronic Diseases

Cardiac Prevention for Chronic Diseases

It is estimated that nearly half of Americans adults have some form of cardiovascular disease.[1] These diseases include diabetes, hypertension, obesity, coronary artery disease, amyloidosis, myocarditis, cardiomyopathy, and many others. Without the ability to test for the effects of chronic diseases early and initiate preventative cardiac treatment, the progression of dysfunction goes unnoticed until cardiac symptoms occur.[2]

MyoStrain® helps physicians identify at-risk patients before symptoms occur by providing visibility into the early progression of myocardial dysfunction across chronic disease states.[3] Physicians may be able to use a proactive management approach to address at-risk patients early and prevent cardiac adverse events.

Primary Care & Concierge

56% of heart failure patients go undiagnosed until after being hospitalized for an adverse event.[4] In order to prevent heart failure, especially in those with a history of chronic disease and/or risk factors, physicians must be able to identify and address at-risk patients at the earliest point of care.

MyoStrain provides a rapid, accurate and non-invasive heart function assessment to help physicians detect early dysfunction and start early treatment. Through this enhanced primary care approach, physicians are better equipped to manage patient heart health at an earlier stage and monitor the individual effects of treatment on their patients.

Primary Care & Concierge

56% of heart failure patients go undiagnosed until after being hospitalized for an adverse event.[4] In order to prevent heart failure, especially in those with a history of chronic disease and/or risk factors, physicians must be able to identify and address at-risk patients at the earliest point of care.

MyoStrain provides a rapid, accurate and non-invasive heart function assessment to help physicians detect early dysfunction and start early treatment. Through this enhanced primary care approach, physicians are better equipped to manage patient heart health at an earlier stage and monitor the individual effects of treatment on their patients.

Primary Care & Concierge

56% of heart failure patients go undiagnosed until after being hospitalized for an adverse event.[4] In order to prevent heart failure, especially in those with a history of chronic disease and/or risk factors, physicians must be able to identify and address at-risk patients at the earliest point of care.

MyoStrain provides a rapid, accurate and non-invasive heart function assessment to help physicians detect early dysfunction and start early treatment. Through this enhanced primary care approach, physicians are better equipped to manage patient heart health at an earlier stage and monitor the individual effects of treatment on their patients.

Cardio-oncology Publications

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
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Cardio-oncology
June 15, 2021
Circulation: Cardiovascular Imaging
CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography
This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019
CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment
This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019

Chronic Disease Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement
This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.
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Chronic Diseases
August 8, 2019
Journal of Cardiovascular Magnetic Resonance

Stress Testing Publications

Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain
This study indicates that in patients presenting with acute chest pain and inconclusive initial clinical screening, MyoStrain can be used to rule out obstructive coronary artery disease. These results show that MyoStrain may serve as a fast and accurate diagnostic tool that could be integrated into clinical workflows.
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Stress Testing
May 3, 2021
PLoS ONE
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
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Stress Testing
April 15, 2021
JACC: Cardiovascular Imaging
Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance
In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.
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Stress Testing
September 1, 2019
Journal of Magnetic Resonance Imaging

Heart Failure Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging
MyoStrain revealed that the LV septum is the location affected most, with reduced values visible in HFpEF and further reductions in HFmrEF and HFrEF where traditional CMR did not detect. This may hold significant socioeconomic implications, possibly aiding the identification of millions of presumable healthy individuals at risk for heart failure, who could benefit from early risk control and treatment.
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Heart Failure
April 1, 2021
ESC Heart Failure
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
References

[1] Cardiovascular diseases affect nearly half of American adults, statistics show. American Heart Association. www.heart.org. (n.d.). [2] What is Heart Failure? American Heart Association. https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure. [3] Korosoglou, G et al. J Am Coll Cardiol Cardiovasc Imaging. Jan 13, 2021. DOI: 10.1016/j.jcmg.2020.10.024. [4] Dunlay, SM, et al. Limetime costs of medical care after heart failure diagnosis. Circulation Cardiovascular Qual Outcomes. 2011;4(1):68-75.