Publications

Research Highlights

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
JACC Cardiovascular Imaging
January 13, 2021
Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure
A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.
BMC Health Economics Review
May 23, 2019
Strain‐encoded magnetic resonance: a method for the assessment of myocardial deformation
This clinical review article describes the history and evolution of the MyoStrain technology. The manuscript itself provides a detailed summary of existing literature about MyoStrain and its predecessor technologies HARP and SENC, totaling 400+ publications representing 70,000+ patient data points to date.
ESC Heart Failure Journal
April 25, 2019
Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
Circulation: Cardiovascular Imaging
June 15, 2021
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
JACC: Cardiovascular Imaging
April 15, 2021
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Journal of Cardiovascular Magnetic Resonance
April 5, 2021

Select MyoStrain® Publications

The MyoStrain technology is rigorously validated across 500+ peer-reviewed publications (including 50+ in JACC and Circulation) representing more than 80,000 patient data points. The following selection contains the most recent and pivotal articles not highlighted above.

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CMR detects decreased myocardial deformation in asymptomatic patients at risk for heart failure
A recently published article from Berlin highlights the potential of MyoStress in terms of identifying at-risk patients who have reserve and are therefore not symptomatic compared to patients with heart failure who have a preserved ejection fraction. This article shows that asymptomatic subjects with increased CV risk present with HFpEF like impaired myocardial deformation at rest, while they show results like controls under HG stress.
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Stress Testing
January 25, 2023
Frontiers in Cardiovascular Medicine
Fast-Strain Encoded Cardiac Magnetic Resonance During Vasodilator Perfusion Stress Testing
This study shows MyoStress was non-inferior to CMR stress testing, with a comparable ability to diagnose and risk stratify CAD patients. This test offers advantages in speed, ease and reproducibility, creating an opportunity for a rapid, cost-effective stress test that gives physicians the ability to evaluate patients efficiently.
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Stress Testing
November 17, 2021
Frontiers in Cardiovascular Medicine
Diagnostic Work-Up of Cardiac Amyloidosis Using Cardiovascular Imaging: Current Standards and Practical Algorithms
This publication evaluates the use of various cardiac imaging techniques in the diagnostic work-up for patients with suspected cardiac amyloidosis, which often presents similarly to other conditions. MyoStrain was able to differentiate and identify cardiac amyloidosis patients, offering a comprehensive evaluation in just a single examination. The ability to diagnose early is crucial to improving cardiac amyloidosis patient outcomes, and MyoStrain’s ability to detect subclinical dysfunction sets it apart from other imaging techniques.
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Risk Stratification
October 23, 2021
Dovepress
Multiparametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance
Results from this publication demonstrated MyoStrain’s accuracy and reproducibility for the detection of cardiac dysfunction across multiple disease states. This highlights MyoStrain's clinical utility in identifying patients in need of care based on the extent and severity of subclinical dysfunction.
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Heart Failure
July 12, 2021
Journal of Cardiovascular Magnetic Resonance
The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study
This publication showcases MyoStrain’s promising clinical utility as a sensitive tool to detect early heart dysfunction over traditional testing methods, irrespective of disease type.
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Heart Failure
June 24, 2021
Journal of Cardiovascular Magnetic Resonance
Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain
This study indicates that in patients presenting with acute chest pain and inconclusive initial clinical screening, MyoStrain can be used to rule out obstructive coronary artery disease. These results show that MyoStrain may serve as a fast and accurate diagnostic tool that could be integrated into clinical workflows.
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Stress Testing
May 3, 2021
PLoS ONE
Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging
MyoStrain revealed that the LV septum is the location affected most, with reduced values visible in HFpEF and further reductions in HFmrEF and HFrEF where traditional CMR did not detect. This may hold significant socioeconomic implications, possibly aiding the identification of millions of presumable healthy individuals at risk for heart failure, who could benefit from early risk control and treatment.
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Heart Failure
April 1, 2021
ESC Heart Failure
Comparison of feature tracking, fast-SENC, and myocardial tagging for global and segmental left ventricular strain
This paper evaluates the accuracy, consistency, and reproducibility of MyoStrain in the assessment of left ventricular function. Authors compared global and segmental strain measurements acquired using MyoStrain (fast-SENC), predecessor technology myocardial tagging, and feature tracking.
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Technical Comparison
December 4, 2019
ESC Heart Failure Journal
Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance
In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.
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Stress Testing
September 1, 2019
Journal of Magnetic Resonance Imaging