Stress Testing

Ischemia Detection

As much as 20% of traditional stress test results produce false positives or negatives.[1] MyoStrain performs a rapid and quantitative assessment of heart function to help reduce the number of unnecessary and suboptimal procedures made on false-positive and false-negative CAD patients. 

In a 15-minute stress test, MyoStress™ helps physicians identify ischemic areas of the heart to rule-out healthy patients while ruling-in at-risk patients to determine a treatment plan best suited to the patient’s condition.[2]

Chest Pain Triage

In the ER today, many of the common cardiac diagnostic tools used provide little explanation for chest pain, and physicians must run several lengthy cardiac tests to find the cause of the patient’s discomfort.[3] These challenges can place constraints on the ER system, potentially leading to capacity issues, unnecessary procedures and suboptimal care.

MyoStrain’s rapid, accurate and non-invasive hyperventilation stress test MyoStress™ is designed to help improve detection, enhance workflow efficiency and optimize care in the ER. Physicians may potentially use MyoStress™ to quantitatively detect ischemia in high-risk chest pain patients while identifying heart dysfunction in lower to at-risk patients and directing them towards the most appropriate care decision.[3] Through this approach, MyoStrain and MyoStress may help to improve outcomes in the ER, enabling physicians to effectively triage their patients based on individual cardiac risk and reduce the number of unnecessary procedures performed.

Chest Pain Triage

In the ER today, many of the common cardiac diagnostic tools used provide little explanation for chest pain, and physicians must run several lengthy cardiac tests to find the cause of the patient’s discomfort.[3] These challenges can place constraints on the ER system, potentially leading to capacity issues, unnecessary procedures and suboptimal care.

MyoStrain’s rapid, accurate and non-invasive hyperventilation stress test MyoStress™ is designed to help improve detection, enhance workflow efficiency and optimize care in the ER. Physicians may potentially use MyoStress™ to quantitatively detect ischemia in high-risk chest pain patients while identifying heart dysfunction in lower to at-risk patients and directing them towards the most appropriate care decision.[3] Through this approach, MyoStrain and MyoStress may help to improve outcomes in the ER, enabling physicians to effectively triage their patients based on individual cardiac risk and reduce the number of unnecessary procedures performed.

Chest Pain Triage

In the ER today, many of the common cardiac diagnostic tools used provide little explanation for chest pain, and physicians must run several lengthy cardiac tests to find the cause of the patient’s discomfort.[3] These challenges can place constraints on the ER system, potentially leading to capacity issues, unnecessary procedures and suboptimal care.

MyoStrain’s rapid, accurate and non-invasive hyperventilation stress test MyoStress™ is designed to help improve detection, enhance workflow efficiency and optimize care in the ER. Physicians may potentially use MyoStress™ to quantitatively detect ischemia in high-risk chest pain patients while identifying heart dysfunction in lower to at-risk patients and directing them towards the most appropriate care decision.[3] Through this approach, MyoStrain and MyoStress may help to improve outcomes in the ER, enabling physicians to effectively triage their patients based on individual cardiac risk and reduce the number of unnecessary procedures performed.

Cardio-oncology Publications

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up
This publication features key outcome data from the PREFECT study demonstrating MyoStrain's ability to help clinicians detect and predict early cardiotoxicity in patients undergoing cancer therapy. These findings highlight MyoStrain as an accurate and sensitive assessment that may enable cardio-oncologists to implement cardio-protective strategies for cancer patients.
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Cardio-oncology
June 15, 2021
Circulation: Cardiovascular Imaging
CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography
This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019
CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment
This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.
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Cardio-oncology
August 31, 2019
Abstract at ESC Congress 2019

Chronic Disease Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement
This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.
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Chronic Diseases
August 8, 2019
Journal of Cardiovascular Magnetic Resonance

Stress Testing Publications

Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain
This study indicates that in patients presenting with acute chest pain and inconclusive initial clinical screening, MyoStrain can be used to rule out obstructive coronary artery disease. These results show that MyoStrain may serve as a fast and accurate diagnostic tool that could be integrated into clinical workflows.
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Stress Testing
May 3, 2021
PLoS ONE
Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol
This article demonstrates MyoStrain’s speed and sensitivity to successfully measure cardiac stress during a safe, simple hyperventilation breathing maneuver. Performed without any pharmacological or physical stress protocols, this new technique may provide clinicians with a faster and safer quantitative stress test to help improve the diagnosis and management of coronary artery disease.
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Stress Testing
April 15, 2021
JACC: Cardiovascular Imaging
Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance
In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.
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Stress Testing
September 1, 2019
Journal of Magnetic Resonance Imaging

Heart Failure Publications

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
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Heart Failure, Chronic Diseases
April 5, 2021
Journal of Cardiovascular Magnetic Resonance
Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging
MyoStrain revealed that the LV septum is the location affected most, with reduced values visible in HFpEF and further reductions in HFmrEF and HFrEF where traditional CMR did not detect. This may hold significant socioeconomic implications, possibly aiding the identification of millions of presumable healthy individuals at risk for heart failure, who could benefit from early risk control and treatment.
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Heart Failure
April 1, 2021
ESC Heart Failure
Fast strain-encoded cardiac magnetic resonance for diagnostic classification and risk stratification of heart failure patients
This article demonstrates MyoStrain's ability to identify patients with subclinical LV dysfunction and those at risk for heart failure-related outcomes compared with LVEF, providing an additional diagnostic window for prevention treatments.
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Heart Failure, Chronic Diseases
January 13, 2021
JACC Cardiovascular Imaging
References

[1] Arbab-Zadeh A. Stress testing and non-invasive coronary angiography in patients with suspected coronary artery disease: time for a new paradigm. Heart Int. 2012 Feb 3; 7(1): e2. doi: 10.4081/hi.2012.e2. [2] Riffel JH, Siry D, Salatzki J, Andre F, Ochs M, Weberling LD, et al. (2021) Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain. PLoS ONE 16(5): e0251040. https://doi.org/10.1371/journal.pone.0251040. [3] Ochs, Met al. J Am Coll Cardiol Cardiovasc Imaging.Apr 14, 2021. DOI: 10.1016/j.jcmg.2021.02.022.