MyoStrain and its predecessor technologies have been published in 400+ peer-reviewed articles, with over 50 in JACC and Circulation. A selection of the MyoStrain research literature is highlighted below.
April 25, 2019
ESC Heart Failure Journal
This clinical review article describes the history and evolution of the MyoStrain technology. The manuscript itself provides a detailed summary of existing literature about MyoStrain and its predecessor technologies HARP and SENC, totaling 400+ publications representing 70,000+ patient data points to date.
Korosoglou G, et al. Strain-encoded magnetic resonance: a method for assessment of myocardial deformation. ESC Heart Failure. 2019 Aug;6(4):584-602.
March 15, 2019
Journal of Medical Economics
An cost-impact analysis of MyoStrain, this manuscript evaluates the cost-saving potential of MyoStrain stress testing for the diagnosis of coronary artery disease in the U.S. The paper offers both a payer and hospital perspective, comparing MyoStrain against the current standard of care single-photon emission computed tomography (SPECT).
Stojanovic I, et al. Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S. Journal of Medical Economics. 2019;22(5):430-438.Read Publication >
March 5, 2019
BMC Cardiovascular Disorders
As a new approach for the rapid assessment of intra-myocardial dysfunction, this paper looks at the speed and clinical efficiency of MyoStrain. Through this method, Myostrain demonstrates rapid quantification of myocardial strain, helping to overcome lengthy CMR scan times and capacity issues.
Lapinskas T, et al. Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function. BMC Cardiovasc Disord. 2019 Mar 5;19(1):52. doi:10.1186/s12872-019-1031-5.Read Publication >
February 1, 2019
International Journal of Cardiovascular Imaging
This publication examines the use of MyoStrain myocardial strain assessment to detect right ventricular dysfunction in patients with pulmonary hypertension.
Oyama-Manabe N, et al. The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension. Int J Cardiovasc Imaging. 2013;29:371-378.Read Publication >
September 20, 2018
In this paper, the authors demonstrate the reproducibility of myocardial strain derived from MyoStrain (fast-SENC) in the quantification and assessment left ventricular heart function.
Giusca S, et al. Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging. Scientific Reports. 2018;8:14100. doi:10.1038/s41598-018-32226-3.Read Publication >
May 1, 2018
This paper demonstrates the clinical application of MyoStrain in the detection of subclinical dysfunction for asymptomatic pediatric cancer patients exposed to anthracycline chemotherapy. Authors used MyoStrain to identify abnormalities using tagging-based segmental myocardial strain.
Toro-Salazar OH, et al. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines. Cardio-Oncology. 2018;4:4. doi:10.1186/s40959-018-0030-5.Read Publication >
May 13, 2016
Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.
Nakano S, et al. Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method. Cardiology Journal. 2016;23(3):270-280.Read Publication >
April 15, 2015
JACC Cardiovascular Imaging
To demonstrate the prognostic value of strain, this study compares the sensitivity of MyoStrain global circumferential strain (GCS) in measuring contractile dysfunction against left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE).
Mordi I, et al. The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR. J Am Coll Cardiol Img. 2015;8:540-9.Read Publication >
September 15, 2014
Journal of Magnetic Resonance Imaging
As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.
Venkatesh BA, et al. Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA). Journal of Magnetic Resonance Imaging. 2015;42:153–159.Read Publication >
April 12, 2014
European Journal of Radiology
An evaluation for the assessment of heart function using CMR-derived strain from MyoStrain (HARP), this paper demonstrates the accuracy of MyoStrain strain tagging for quantifying segmental function, as compared to late gadolinium enhancement (LGE).
Wong DTL, et al. Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction. Eur Radiol. 2014;24:1219-1228.Read Publication >
October 4, 2013
Circulation Cardiovascular Imaging
This paper demonstrates the clinical utility of MyoStrain in detecting subclinical dysfunction from cardiotoxicity in asymptomatic pediatric cancer survivors. Results acquired using MyoStrain's segmental myocardial strain analysis were compared to global measures derived from echocardiography and traditional CMR.
Toro-Salazar OH, et al. Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy. Circ Cardiovasc Imaging. 2013;6:873-880.Read Publication >