MyoStrain Research

MyoStrain and its predecessor technologies have been published in 400+ peer-reviewed articles, with over 50 in JACC and Circulation. A selection of the MyoStrain research literature is highlighted below.

May 23, 2019

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BMC Health Economics Review

Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure

A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.

Schneider, J.E., Stojanovic, I. Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure. Health Econ Rev 9, 13 (2019).

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March 15, 2019

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Journal of Medical Economics

Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S.

An cost-impact analysis of MyoStrain, this manuscript evaluates the cost-saving potential of MyoStrain stress testing for the diagnosis of coronary artery disease in the U.S. The paper offers both a payer and hospital perspective, comparing MyoStrain against the current standard of care single-photon emission computed tomography (SPECT).

Stojanovic I, et al. Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S. Journal of Medical Economics. 2019;22(5):430-438.

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March 5, 2019

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BMC Cardiovascular Disorders

Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function

As a new approach for the rapid assessment of intra-myocardial dysfunction, this paper looks at the speed and clinical efficiency of MyoStrain. Through this method, Myostrain demonstrates rapid quantification of myocardial strain, helping to overcome lengthy CMR scan times and capacity issues.

Lapinskas T, et al. Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function. BMC Cardiovasc Disord. 2019 Mar 5;19(1):52. doi:10.1186/s12872-019-1031-5.

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February 1, 2019

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International Journal of Cardiovascular Imaging

The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension

This publication examines the use of MyoStrain myocardial strain assessment to detect right ventricular dysfunction in patients with pulmonary hypertension.

Oyama-Manabe N, et al. The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension. Int J Cardiovasc Imaging. 2013;29:371-378.

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September 20, 2018

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Scientific Reports

Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging

In this paper, the authors demonstrate the reproducibility of myocardial strain derived from MyoStrain (fast-SENC) in the quantification and assessment left ventricular heart function.

Giusca S, et al. Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging. Scientific Reports. 2018;8:14100. doi:10.1038/s41598-018-32226-3.

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May 1, 2018

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Cardio-Oncology

Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines

This paper demonstrates the clinical application of MyoStrain in the detection of subclinical dysfunction for asymptomatic pediatric cancer patients exposed to anthracycline chemotherapy. Authors used MyoStrain to identify abnormalities using tagging-based segmental myocardial strain.

Toro-Salazar OH, et al. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines. Cardio-Oncology. 2018;4:4. doi:10.1186/s40959-018-0030-5.

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May 13, 2016

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Cardiology Journal

Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method

Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.

Nakano S, et al. Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method. Cardiology Journal. 2016;23(3):270-280.

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April 15, 2015

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JACC Cardiovascular Imaging

The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR

To demonstrate the prognostic value of strain, this study compares the sensitivity of MyoStrain global circumferential strain (GCS) in measuring contractile dysfunction against left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE).

Mordi I, et al. The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR. J Am Coll Cardiol Img. 2015;8:540-9.

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September 15, 2014

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Journal of Magnetic Resonance Imaging

Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA)

As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.

Venkatesh BA, et al. Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA). Journal of Magnetic Resonance Imaging. 2015;42:153–159.

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April 12, 2014

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European Journal of Radiology

Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction

An evaluation for the assessment of heart function using CMR-derived strain from MyoStrain (HARP), this paper demonstrates the accuracy of MyoStrain strain tagging for quantifying segmental function, as compared to late gadolinium enhancement (LGE).

Wong DTL, et al. Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction. Eur Radiol. 2014;24:1219-1228.

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