MyoStrain Research
MyoStrain and its predecessor technologies have been published in 400+ peer-reviewed articles, with over 50 in JACC and Circulation. A selection of the MyoStrain research literature is highlighted below.
April 5, 2021
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Journal of Cardiovascular Magnetic Resonance
Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis
The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.
Steen, H., et al. J Cardiovasc Magn Reson 23, 45(2021). https://doi.org/10.1186/s12968-021-00711-w
Read Publication >December 4, 2019
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ESC Heart Failure Journal
Comparison of feature tracking, fast-SENC, and myocardial tagging for global and segmental left ventricular strain
This paper evaluates the accuracy, consistency, and reproducibility of MyoStrain in the assessment of left ventricular function. Authors compared global and segmental strain measurements acquired using MyoStrain (fast-SENC), predecessor technology myocardial tagging, and feature tracking.
Bucius P, et al. Comparison of feature tracking, fast-SENC, and myocardial tagging for global and segmental left ventricular strain. ESC Heart Failure. 2019 Dec 4. doi:10.1002/ehf2.12576.
Read Publication >September 1, 2019
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Journal of Magnetic Resonance Imaging
Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance
In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.
Kawaji K, et al. Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance. Magn Reson Imaging. 2019 Sep 1. doi:10.1016/j.mri.2019.08.033.
Read Publication >August 31, 2019
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Abstract at ESC Congress 2019
CMR fast-SENC segmental intramyocardial LV strain detects heart disease progression based on ACC/AHA Heart Failure stage before global longitudinal strain or ejection fraction
This new abstract explores MyoStrain's ability to follow the progression of heart disease based on American College of Cardiology and American Heart Association heart failure stages using segmental intramyocardial strain metrics.
Montenbruck M, et al. CMR fast-SENC segmental intramyocardial LV strain detects heart disease progression based on ACC/AHA Heart Failure stage before global longitudinal strain or ejection fraction. ESC Congress 2019. P600.
Read Publication >August 31, 2019
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Abstract at ESC Congress 2019
Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction
A new abstract studies MyoStrain's (fast-SENC) ability to assess right ventricular cardiac dysfunction, as well as to monitor the effects of treatment and device interventions using segmental myocardial strain.
Montenbruck M, et al. Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction. ESC Congress 2019. P4304.
Read Publication >August 31, 2019
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Abstract at ESC Congress 2019
CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography
This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.
Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography. ESC Congress 2019. P3118.
Read Publication >August 31, 2019
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Abstract at ESC Congress 2019
CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment
This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.
Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment. ESC Congress 2019. P3554.
Read Publication >August 31, 2019
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Abstract at ESC Congress 2019
Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain
In this abstract, authors utilize MyoStrain's non-invasive hyperventilation stress test to help physicians detect ischemic coronary artery disease in chest pain patients entering the ER.
Siry D, et al. Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain. ESC Congress 2019. P2718.
Read Publication >August 21, 2019
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Scientific Reports
Effect of comprehensive initial training on the variability of left ventricular measures using fast-SENC cardiac magnetic resonance imaging
An article discussing the effects of experience using MyoStrain on accuracy of test results, this article demonstrates consistency and reproducibility of MyoStrain results independent of operator expertise.
Lapinskas T, et al. Effect of comprehensive initial training on the variability of left ventricular measures using fast-SENC cardiac magnetic resonance imaging. Sci Rep. 2019 Aug 21;9(1):12223. doi:10.1038/s41598-019-48685-1.
Read Publication >August 8, 2019
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Journal of Cardiovascular Magnetic Resonance
Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement
This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.
Erley J, et al. Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement. Journal of Cardiovascular Magnetic Resonance. 2019;21:46. doi:10.1186/s12968-019-0559-y.
Read Publication >May 23, 2019
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BMC Health Economics Review
Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure
A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.
Schneider, J.E., Stojanovic, I. Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure. Health Econ Rev 9, 13 (2019).
Read Publication >March 15, 2019
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Journal of Medical Economics
Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S.
An cost-impact analysis of MyoStrain, this manuscript evaluates the cost-saving potential of MyoStrain stress testing for the diagnosis of coronary artery disease in the U.S. The paper offers both a payer and hospital perspective, comparing MyoStrain against the current standard of care single-photon emission computed tomography (SPECT).
Stojanovic I, et al. Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S. Journal of Medical Economics. 2019;22(5):430-438.
Read Publication >March 5, 2019
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BMC Cardiovascular Disorders
Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function
As a new approach for the rapid assessment of intra-myocardial dysfunction, this paper looks at the speed and clinical efficiency of MyoStrain. Through this method, Myostrain demonstrates rapid quantification of myocardial strain, helping to overcome lengthy CMR scan times and capacity issues.
Lapinskas T, et al. Strain-encoded cardiac magnetic resonance imaging: a new approach for fast estimation of left ventricular function. BMC Cardiovasc Disord. 2019 Mar 5;19(1):52. doi:10.1186/s12872-019-1031-5.
Read Publication >February 1, 2019
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International Journal of Cardiovascular Imaging
The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension
This publication examines the use of MyoStrain myocardial strain assessment to detect right ventricular dysfunction in patients with pulmonary hypertension.
Oyama-Manabe N, et al. The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension. Int J Cardiovasc Imaging. 2013;29:371-378.
Read Publication >September 20, 2018
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Scientific Reports
Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging
In this paper, the authors demonstrate the reproducibility of myocardial strain derived from MyoStrain (fast-SENC) in the quantification and assessment left ventricular heart function.
Giusca S, et al. Reproducibility study on myocardial strain assessment using fast-SENC cardiac magnetic resonance imaging. Scientific Reports. 2018;8:14100. doi:10.1038/s41598-018-32226-3.
Read Publication >May 1, 2018
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Cardio-Oncology
Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines
This paper demonstrates the clinical application of MyoStrain in the detection of subclinical dysfunction for asymptomatic pediatric cancer patients exposed to anthracycline chemotherapy. Authors used MyoStrain to identify abnormalities using tagging-based segmental myocardial strain.
Toro-Salazar OH, et al. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines. Cardio-Oncology. 2018;4:4. doi:10.1186/s40959-018-0030-5.
Read Publication >May 13, 2016
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Cardiology Journal
Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method
Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.
Nakano S, et al. Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method. Cardiology Journal. 2016;23(3):270-280.
Read Publication >April 15, 2015
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JACC Cardiovascular Imaging
The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR
To demonstrate the prognostic value of strain, this study compares the sensitivity of MyoStrain global circumferential strain (GCS) in measuring contractile dysfunction against left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE).
Mordi I, et al. The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR. J Am Coll Cardiol Img. 2015;8:540-9.
Read Publication >September 15, 2014
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Journal of Magnetic Resonance Imaging
Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA)
As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.
Venkatesh BA, et al. Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA). Journal of Magnetic Resonance Imaging. 2015;42:153–159.
Read Publication >April 12, 2014
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European Journal of Radiology
Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction
An evaluation for the assessment of heart function using CMR-derived strain from MyoStrain (HARP), this paper demonstrates the accuracy of MyoStrain strain tagging for quantifying segmental function, as compared to late gadolinium enhancement (LGE).
Wong DTL, et al. Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction. Eur Radiol. 2014;24:1219-1228.
Read Publication >October 4, 2013
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Circulation Cardiovascular Imaging
Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy
This paper demonstrates the clinical utility of MyoStrain in detecting subclinical dysfunction from cardiotoxicity in asymptomatic pediatric cancer survivors. Results acquired using MyoStrain's segmental myocardial strain analysis were compared to global measures derived from echocardiography and traditional CMR.
Toro-Salazar OH, et al. Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy. Circ Cardiovasc Imaging. 2013;6:873-880.
Read Publication >August 1, 2013
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JACC Cardiovascular Imaging
Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease
In this article, authors evaluate the use of MyoStrain myocardial strain to detect early cardiotoxicity in patients exposed to anthracycline-based chemotherapy.
Drafts BC, et al. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013 August;6(8):877-885.
Read Publication >May 3, 2013
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European Heart Journal
Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis.
An ongoing study conducted at Johns Hopkins University, the MESA Study evaluates the clinical utility and prognostic value of circumferential strain using MyoStrain (fast-SENC) to predict heart failure and stratify heart failure risk in asymptomatic patients.
Choi EY, et al. Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis. European Heart Journal. 2013;34:2354-2361.
Read Publication >January 1, 2013
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Radiology
Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR study
An article observing the assessment of biventricular heart function using MyoStrain, MyoStrain demonstrates its ability to help identify RV intra-myocardial dysfunction in patients with pulmonary hypertension.
Shehata ML, et al. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR study. Radiology. 2013;266(1):114-122.
Read Publication >November 8, 2011
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International Journal of Cardiology
Layer-specific strain-encoded MRI for the evaluation of left ventricular function and infarct transmurality in patients with chronic coronary artery disease
This study evaluates the use of MyoStrain (SENC) for quantifying segmental myocardial strain to help determine LV heart function in patients with chronic coronary artery disease (CAD).
Koos R, et al. Layer-specific strain-encoded MRI for the evaluation of left ventricular function and infarct transmurality in patients with chronic coronary artery disease. International Journal of Cardiology. 2013;166:85-89.
Read Publication >September 6, 2011
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JACC Cardiovascular Imaging
Strain-Encoded Cardiac Magnetic Resonance During High-Dose Dobutamine Stress Testing for the Estimation of Cardiac Outcomes
This paper demonstrates MyoStrain's clinical utility in the rapid assessment and quantification of ischemia to help guide clinical decision-making for chest pain patients entering the ER.
Korosoglou G, et al. Strain-Encoded Cardiac Magnetic Resonance During High-Dose Dobutamine Stress Testing for the Estimation of Cardiac Outcomes. J Am Coll Cardiol 2011;58:1140–9. (Strain-Encoded Cardiac Magnetic Resonance Imaging as an Adjunct for Dobutamine Stress Testing; NCT00758654)
Read Publication >June 18, 2011
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European Journal of Radiology
Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla
Authors use circumferential and longitundal strain acquired from MyoStrain rapid strain-encoding (fast-SENC) to measure and identify old myocardial infarction as well as differentiate subendocardial from transmural infarction.
Oyama-Manabe N, et al. Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla. Eur Radiol. 2011. doi:10.1007/s00330-011-2177-4.
Read Publication >March 11, 2011
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Journal of Cardiovascular Magnetic Resonance
Prevalence and distribution of regional scar in dysfunctional myocardial segments in Duchenne muscular dystrophy
This article demonstrates the reproducibility, efficacy, and broad clinical applications of MyoStrain predecessor HARP by utilizing HARP's tagging-based strain to detect subclinical cardiac dysfunction in Duchenne muscular dystrophy (DMD), as compared against ECHO-derived global strain.
Bilchick KC, et al. Prevalence and distribution of regional scar in dysfunctional myocardial segments in Duchenne muscular dystrophy. Journal of Cardiovascular Magnetic Resonance. 2011;13(20):1-8.
Read Publication >January 1, 2011
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American Journal of Roentgenology
Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling
This paper demonstrates the clinical utility of MyoStrain segmental myocardial strain analysis to detect right ventricular dysfunction in patients with pulmonary hypertension.
Shehata M, et al. Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling. Am J Roentgenol. 2011 January;196(1):87-94.
Read Publication >June 22, 2010
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Magnetic Resonance in Medicine
Real-time single-heartbeat fast strain-encoded imaging of right ventricular regional function: normal versus chronic pulmonary hypertension
In this paper, MyoStrain (fast-SENC) is evaluated for its rapid, real-time assessment of right ventricular function in patients with normal and chronic pulmonary hypertension using segmental myocardial strain.
Shehata ML, et al. Real-time single-heartbeat fast strain-encoded imaging of right ventricular regional function: normal versus chronic pulmonary hypertension. Magnetic Resonance in Medicine. 2010;64:98-106.
Read Publication >April 1, 2010
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JACC Cardiovascular Imaging
Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress
This paper utilizes MyoStrain's non-invasive stress test technique to identify subtle changes in heart function indicative of ischemia in patients suspected of coronary artery disease.
Korosoglou G, et al. Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress. J Am Coll Cardiol Img. 2010;3: 361–71. (Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing; NCT00758654)
Read Publication >April 1, 2009
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Journal of American College of Cardiology
Circumferential Strain Analysis Identifies Strata of Cardiomyopathy in Duchenne Muscular Dystrophy A Cardiac Magnetic Resonance Tagging Study
This article demonstrates the reproducibility, efficacy and broad clinical applications of MyoStrain predecessor HARP by occult cardiac dysfunction in Duchenne muscular dystrophy (DMD), as compared against left ventricular ejection fraction (LVEF).
Hor KN, et al. Circumferential Strain Analysis Identifies Strata of Cardiomyopathy in Duchenne Muscular Dystrophy A Cardiac Magnetic Resonance Tagging Study. J Am Coll Cardiol 2009;53:1204–10.
Read Publication >January 26, 2009
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Circulation Cardiovascular Imaging
Strain-encoded MRI for evaluation of left ventricular function and transmurality in acute myocardial infarction
This article shows MyoStrain's ability to directly quantify segmental heart function using MyoStrain's SENC MRI pulse sequence, treatment scale and post-processing analysis of dysfunction in acute myocardial infarction (AMI) patients.
Neizel M, et al. Strain-Encoded MRI for Evaluation of Left Ventricular Function and Transmurality in Acute Myocardial Infarction. Circ Cardiovasc Imaging. 2009;2:116-122.
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