MyoStrain Research

MyoStrain and its predecessor technologies have been published in 400+ peer-reviewed articles, with over 50 in JACC and Circulation. A selection of the MyoStrain research literature is highlighted below.

April 5, 2021

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Journal of Cardiovascular Magnetic Resonance

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis

The study compared MyoStrain’s ability to quantify and differentiate asymptomatic patients based on their cardiac risk versus traditional ejection faction, reiterating the technology's potential as a critical cardiac risk stratification tool enabling clinicians to identify at-risk patients early for individualized preventative treatment.

Steen, H., et al. J Cardiovasc Magn Reson 23, 45(2021). https://doi.org/10.1186/s12968-021-00711-w

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December 4, 2019

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ESC Heart Failure Journal

Comparison of feature tracking, fast-SENC, and myocardial tagging for global and segmental left ventricular strain

This paper evaluates the accuracy, consistency, and reproducibility of MyoStrain in the assessment of left ventricular function. Authors compared global and segmental strain measurements acquired using MyoStrain (fast-SENC), predecessor technology myocardial tagging, and feature tracking.

Bucius P, et al. Comparison of feature tracking, fast-SENC, and myocardial tagging for global and segmental left ventricular strain. ESC Heart Failure. 2019 Dec 4. doi:10.1002/ehf2.12576.

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September 1, 2019

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Journal of Magnetic Resonance Imaging

Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance

In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.

Kawaji K, et al. Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance. Magn Reson Imaging. 2019 Sep 1. doi:10.1016/j.mri.2019.08.033.

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August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC segmental intramyocardial LV strain detects heart disease progression based on ACC/AHA Heart Failure stage before global longitudinal strain or ejection fraction

This new abstract explores MyoStrain's ability to follow the progression of heart disease based on American College of Cardiology and American Heart Association heart failure stages using segmental intramyocardial strain metrics.

Montenbruck M, et al. CMR fast-SENC segmental intramyocardial LV strain detects heart disease progression based on ACC/AHA Heart Failure stage before global longitudinal strain or ejection fraction. ESC Congress 2019. P600.

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August 31, 2019

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Abstract at ESC Congress 2019

Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction

A new abstract studies MyoStrain's (fast-SENC) ability to assess right ventricular cardiac dysfunction, as well as to monitor the effects of treatment and device interventions using segmental myocardial strain.

Montenbruck M, et al. Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction. ESC Congress 2019. P4304.

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August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography

This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography. ESC Congress 2019. P3118.

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August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment

This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment. ESC Congress 2019. P3554.

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August 31, 2019

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Abstract at ESC Congress 2019

Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain

In this abstract, authors utilize MyoStrain's non-invasive hyperventilation stress test to help physicians detect ischemic coronary artery disease in chest pain patients entering the ER.

Siry D, et al. Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain. ESC Congress 2019. P2718.

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August 21, 2019

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Scientific Reports

Effect of comprehensive initial training on the variability of left ventricular measures using fast-SENC cardiac magnetic resonance imaging

An article discussing the effects of experience using MyoStrain on accuracy of test results, this article demonstrates consistency and reproducibility of MyoStrain results independent of operator expertise.

Lapinskas T, et al. Effect of comprehensive initial training on the variability of left ventricular measures using fast-SENC cardiac magnetic resonance imaging. Sci Rep. 2019 Aug 21;9(1):12223. doi:10.1038/s41598-019-48685-1.

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August 8, 2019

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Journal of Cardiovascular Magnetic Resonance

Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement

This paper evaluates and compares MyoStrain's ability to detect fibrosis based on late gadolinium enhancement versus speckle tracking echocardiography.

Erley J, et al. Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement. Journal of Cardiovascular Magnetic Resonance. 2019;21:46. doi:10.1186/s12968-019-0559-y.

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