Clinical Applications

Partnering Across Clinical Practices

MyoStrain provides innovative solutions to help meet the clinical needs of physicians and providers. From early cardiac detection to long-term patient monitoring, MyoStrain collaborates with healthcare providers to standardize cardiac patient management and help prevent adverse events for patients at risk of heart failure.

Cardio-Oncology

nurse shares test results with cancer patient

Today's Clinical Challenge

Today, cardiologists have several therapies to protect the heart but lack the visibility needed to quantify cardio-toxicity or manage the effects of cardio-protective therapy without interrupting cancer treatment.

How MyoStrain Can Help

MyoStrain enables physicians reliably measure the cardio-toxic effects of chemotherapy in cancer patients. This helps physicians to determine cardio-protective agents and dosage, as well as monitor and manage treatment.¹

myostrain research icon

Clinical Evidence

August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography

This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography. ESC Congress 2019. P3118.

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August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment

This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment. ESC Congress 2019. P3554.

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May 1, 2018

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Cardio-Oncology

Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines

This paper demonstrates the clinical application of MyoStrain in the detection of subclinical dysfunction for asymptomatic pediatric cancer patients exposed to anthracycline chemotherapy. Authors used MyoStrain to identify abnormalities using tagging-based segmental myocardial strain.

Toro-Salazar OH, et al. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines. Cardio-Oncology. 2018;4:4. doi:10.1186/s40959-018-0030-5.

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May 13, 2016

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Cardiology Journal

Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method

Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.

Nakano S, et al. Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method. Cardiology Journal. 2016;23(3):270-280.

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October 4, 2013

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Circulation Cardiovascular Imaging

Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy

This paper demonstrates the clinical utility of MyoStrain in detecting subclinical dysfunction from cardiotoxicity in asymptomatic pediatric cancer survivors. Results acquired using MyoStrain's segmental myocardial strain analysis were compared to global measures derived from echocardiography and traditional CMR.

Toro-Salazar OH, et al. Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy. Circ Cardiovasc Imaging. 2013;6:873-880.

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August 1, 2013

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JACC Cardiovascular Imaging

Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease

In this article, authors evaluate the use of MyoStrain myocardial strain to detect early cardiotoxicity in patients exposed to anthracycline-based chemotherapy.

Drafts BC, et al. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013 August;6(8):877-885.

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ER Chest Pain Triage

doctor tends to hospital patient

Today's Clinical Challenge

As much as 40% of catheterizations performed are false positive and 15% are false negative.² Today, long exam times and/or poor information make it difficult to quickly or efficiently triage patients. This inefficiency in the ER results in waste from unnecessary procedures and suboptimal care.

How MyoStrain Can Help

MyoStrain uniquely identifies ischemia by providing a rapid and noninvasive stress test via a six-heartbeat MRI scan. This can help improve workflow efficiency, reduce the number of unnecessary procedures, and provide optimal care.

Clinical Evidence

September 1, 2019

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Journal of Magnetic Resonance Imaging

Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance

In this article, MyoStrain provides a rapid and quantitative assessment of segmental myocardial strain to help reliably detect ischemia in patients suspected in coronary artery disease.

Kawaji K, et al. Quantitative detection of changes in regional wall motion using real time strain-encoded cardiovascular magnetic resonance. Magn Reson Imaging. 2019 Sep 1. doi:10.1016/j.mri.2019.08.033.

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August 31, 2019

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Abstract at ESC Congress 2019

Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain

In this abstract, authors utilize MyoStrain's non-invasive hyperventilation stress test to help physicians detect ischemic coronary artery disease in chest pain patients entering the ER.

Siry D, et al. Interim study: analysis of myocardial deformation using fSENC-CMR on patients with chest pain. ESC Congress 2019. P2718.

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March 15, 2019

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Journal of Medical Economics

Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S.

An cost-impact analysis of MyoStrain, this manuscript evaluates the cost-saving potential of MyoStrain stress testing for the diagnosis of coronary artery disease in the U.S. The paper offers both a payer and hospital perspective, comparing MyoStrain against the current standard of care single-photon emission computed tomography (SPECT).

Stojanovic I, et al. Cost-impact of cardiac magnetic resonance imaging with fast-SENC compared to SPECT in the diagnosis of ischemic coronary artery disease in the U.S. Journal of Medical Economics. 2019;22(5):430-438.

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November 8, 2011

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International Journal of Cardiology

Layer-specific strain-encoded MRI for the evaluation of left ventricular function and infarct transmurality in patients with chronic coronary artery disease

This study evaluates the use of MyoStrain (SENC) for quantifying segmental myocardial strain to help determine LV heart function in patients with chronic coronary artery disease (CAD).

Koos R, et al. Layer-specific strain-encoded MRI for the evaluation of left ventricular function and infarct transmurality in patients with chronic coronary artery disease. International Journal of Cardiology. 2013;166:85-89.

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September 6, 2011

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JACC Cardiovascular Imaging

Strain-Encoded Cardiac Magnetic Resonance During High-Dose Dobutamine Stress Testing for the Estimation of Cardiac Outcomes

This paper demonstrates MyoStrain's clinical utility in the rapid assessment and quantification of ischemia to help guide clinical decision-making for chest pain patients entering the ER.

Korosoglou G, et al. Strain-Encoded Cardiac Magnetic Resonance During High-Dose Dobutamine Stress Testing for the Estimation of Cardiac Outcomes. J Am Coll Cardiol 2011;58:1140–9. (Strain-Encoded Cardiac Magnetic Resonance Imaging as an Adjunct for Dobutamine Stress Testing; NCT00758654)

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April 1, 2010

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JACC Cardiovascular Imaging

Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress

This paper utilizes MyoStrain's non-invasive stress test technique to identify subtle changes in heart function indicative of ischemia in patients suspected of coronary artery disease.

Korosoglou G, et al. Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress. J Am Coll Cardiol Img. 2010;3: 361–71. (Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing; NCT00758654)

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Preventative Care

man jogging on pier

Today's Clinical Challenge

It is estimated that nearly half of Americans will have some form of cardiovascular disease by 2035.³ Without the ability to test for the effects of chronic diseases early and initiate cardiac preventative treatment, the progression of dysfunction goes unnoticed until cardiac symptoms occur.

How MyoStrain Can Help

MyoStrain helps physicians identify patients at risk of heart failure before adverse symptoms occur by providing visibility into the early progression of myocardial dysfunction across 13 chronic disease states.⁴ Physicians may initiate a proactive management approach to address at-risk patients early and prevent heart failure.

Clinical Evidence

August 31, 2019

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Abstract at ESC Congress 2019

Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction

A new abstract studies MyoStrain's (fast-SENC) ability to assess right ventricular cardiac dysfunction, as well as to monitor the effects of treatment and device interventions using segmental myocardial strain.

Montenbruck M, et al. Fast-SENC quantifies segmental right ventricular intramyocardial strain to assess subclinical RV dysfunction prior to changes in RV ejection fraction. ESC Congress 2019. P4304.

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August 31, 2019

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Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography

This abstract utilizes MyoStrain in the early detection of cardiotoxicity for patients undergoing oncology treatment, as compared to echocardiography. The abstract also examines the effectiveness of cardio-protection, utilizing MyoStrain to monitor and manage the effects of cardioprotective therapy on patient heart function.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain detects cardiotoxicity during oncology treatment and impact of cardioprotection therapy before echocardiography. ESC Congress 2019. P3118.

Read Publication >

August 31, 2019

|

Abstract at ESC Congress 2019

CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment

This abstract demonstrates the clinical application of MyoStrain as a tool to help quantify, monitor, and manage cardio-protection for oncology patients exhibiting cardiotoxicity.

Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment. ESC Congress 2019. P3554.

Read Publication >

May 13, 2016

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Cardiology Journal

Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method

Authors utilize MyoStrain's myocardial strain assessment to quantify subclinical cardiotoxicity in breast cancer patients exposed to trastuzumab-based chemotherapy.

Nakano S, et al. Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method. Cardiology Journal. 2016;23(3):270-280.

Read Publication >

April 15, 2015

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JACC Cardiovascular Imaging

The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR

To demonstrate the prognostic value of strain, this study compares the sensitivity of MyoStrain global circumferential strain (GCS) in measuring contractile dysfunction against left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE).

Mordi I, et al. The combined incremental prognostic value of LVEF, late gadolinium enhancement, and global circumferential strain assessed by CMR. J Am Coll Cardiol Img. 2015;8:540-9.

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September 15, 2014

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Journal of Magnetic Resonance Imaging

Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA)

As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.

Venkatesh BA, et al. Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA). Journal of Magnetic Resonance Imaging. 2015;42:153–159.

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May 3, 2013

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European Heart Journal

Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis.

An ongoing study conducted at Johns Hopkins University, the MESA Study evaluates the clinical utility and prognostic value of circumferential strain using MyoStrain (fast-SENC) to predict heart failure and stratify heart failure risk in asymptomatic patients.

Choi EY, et al. Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis. European Heart Journal. 2013;34:2354-2361.

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Heart Failure Management

grandfather spending time with grandchildren

Today's Clinical Challenge

Today's diagnostic tests are insensitive to the progression of dysfunction. As a result, physicians are blind to the changing effects of various treatments on the heart. This complicates physicians' ability to manage and optimize treatment, as acute heart failure patients may be taking an average of 6 different drugs with potentially interacting effects.⁵

How MyoStrain Can Help

MyoStrain provides data-driven insight to help physicians select and dose therapy effectively. By quantifying the effects of treatment over time, MyoStrain enables physicians to focus on reducing re-hospitalizations and improving patient quality of life.

Clinical Evidence

May 23, 2019

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BMC Health Economics Review

Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure

A cost-impact analysis of MyoStrain in the early diagnosis and management of MyoStrain, this manuscript compares the cost-saving potential of MyoStrain versus echocardiography.

Schneider, J.E., Stojanovic, I. Economic evaluation of cardiac magnetic resonance with fast-SENC in the diagnosis and management of early heart failure. Health Econ Rev 9, 13 (2019).

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September 15, 2014

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Journal of Magnetic Resonance Imaging

Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA)

As part of the MESA study, this article utilizes MyoStrain (fast-SENC) to characterize left ventricular regional deformation patterns to provide a baseline for quantifying heart health and stratifying heart failure risk in asymptomatic patients.

Venkatesh BA, et al. Regional myocardial functional patterns: quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: the multi-ethnic study of atherosclerosis (MESA). Journal of Magnetic Resonance Imaging. 2015;42:153–159.

Read Publication >

April 12, 2014

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European Journal of Radiology

Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction

An evaluation for the assessment of heart function using CMR-derived strain from MyoStrain (HARP), this paper demonstrates the accuracy of MyoStrain strain tagging for quantifying segmental function, as compared to late gadolinium enhancement (LGE).

Wong DTL, et al. Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction. Eur Radiol. 2014;24:1219-1228.

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May 3, 2013

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European Heart Journal

Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis.

An ongoing study conducted at Johns Hopkins University, the MESA Study evaluates the clinical utility and prognostic value of circumferential strain using MyoStrain (fast-SENC) to predict heart failure and stratify heart failure risk in asymptomatic patients.

Choi EY, et al. Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis. European Heart Journal. 2013;34:2354-2361.

Read Publication >

June 18, 2011

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European Journal of Radiology

Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla

Authors use circumferential and longitundal strain acquired from MyoStrain rapid strain-encoding (fast-SENC) to measure and identify old myocardial infarction as well as differentiate subendocardial from transmural infarction.

Oyama-Manabe N, et al. Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla. Eur Radiol. 2011. doi:10.1007/s00330-011-2177-4.

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January 26, 2009

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Circulation Cardiovascular Imaging

Strain-encoded MRI for evaluation of left ventricular function and transmurality in acute myocardial infarction

This article shows MyoStrain's ability to directly quantify segmental heart function using MyoStrain's SENC MRI pulse sequence, treatment scale and post-processing analysis of dysfunction in acute myocardial infarction (AMI) patients.

Neizel M, et al. Strain-Encoded MRI for Evaluation of Left Ventricular Function and Transmurality in Acute Myocardial Infarction. Circ Cardiovasc Imaging. 2009;2:116-122.

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REFERENCES

1. Steen H, et al. CMR fast-SENC intramyocardial LV & RV segmental strain helps manage cardioprotective therapy in patients exhibiting cardiotoxicity during cancer treatment. ESC Congress 2019. P3554.
2. Korosglou G, et al. J Am Coll Cardiol 2011.
3. American Heart Association. CVD Burden Report 2017.
4. Montenbruck M, et al. CMR fast-SENC segmental intramyocardial LV strain detects heart disease progression based on ACC/AHA Heart Failure stage before global longitudinal strain or ejection fraction. ESC Congress 2019. P600.
5. Custodis F, et al. Patient Prefer Adherence 2016. doi:10.2147/PPA.S113912